Scholarlink

<p>Hybrid molecules based on 18<i>β</i>-glycyrrhetic acid (GLA), i.e., conjugates of GLA methyl ester 3-<i>O</i>-hemisuccinate with methyl/ethyl esters of <i>L</i>-amino acids (isoleucine, leucine, phenylalanine), were synthesized in 50–55% yields using <i>N</i>-hydroxysuccinimide–<i>N,N</i>′-dicyclohexylcarbodiimide. The conjugate with <i>L</i>-leucine methyl ester (<b>5</b>) showed pronounced antiviral activity against human adenovirus type 5.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis of Amino-Acid Conjugates of 18β-Glycyrrhetic Acid Methyl Ester 3-O-Hemisuccinate

  • 期刊论文

  • 发表日期：

    2025年7月24日

查看全文
  • L. A. Baltina,
  • E. R. Karimova,
  • S. F. Petrova,
  • P. A. Ilyina,
  • I. S. Balashova,
  • V. V. Zarubaev

摘要

Hybrid molecules based on 18β-glycyrrhetic acid (GLA), i.e., conjugates of GLA methyl ester 3-O-hemisuccinate with methyl/ethyl esters of L-amino acids (isoleucine, leucine, phenylalanine), were synthesized in 50–55% yields using N-hydroxysuccinimide–N,N′-dicyclohexylcarbodiimide. The conjugate with L-leucine methyl ester (5) showed pronounced antiviral activity against human adenovirus type 5.