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<p>Two previously undescribed iridoid glycosides, 6′-<i>O</i>-trans-caffeoyl-(4<i>S</i>,6<i>R</i>)-3,4-dihydro-3<i>α</i>- methylthioasperulosid (<b>1</b>) and 6′-<i>O</i>-trans-feruloyl-(4<i>S</i>,6<i>R</i>)-3,4-dihydro-2′-<i>O</i>-3<i>α</i>-paederosid (<b>2</b>), were isolated from the 90% EtOH extract of the aerial part of <i>Paederia foetida</i> L. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H–<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, HR-ESI-MS, as well as ECD data. The isolated compounds were tested in vitro for cytotoxic activity against five tumor cell lines. These results revealed that <b>2</b> exhibited some cytotoxicities against all the tested tumor cell lines with IC<sub>50</sub> value less than 20.0 μM and provided a scientific basis for further processing and utilization of <i>P. foetida</i>.</p>

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Cytotoxic Iridoid Glycosides from the Aerial Parts of Paederia foetida

  • 期刊论文

  • 发表日期：

    2025年7月19日

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  • Jiang Hu,
  • Guihua Yu,
  • Fengming Xu,
  • Tao Lv,
  • Qiang Li,
  • Feng Gao

摘要

Two previously undescribed iridoid glycosides, 6′-O-trans-caffeoyl-(4S,6R)-3,4-dihydro-3α- methylthioasperulosid (1) and 6′-O-trans-feruloyl-(4S,6R)-3,4-dihydro-2′-O-3α-paederosid (2), were isolated from the 90% EtOH extract of the aerial part of Paederia foetida L. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H–1H COSY, HMQC, and HMBC) NMR spectroscopy, HR-ESI-MS, as well as ECD data. The isolated compounds were tested in vitro for cytotoxic activity against five tumor cell lines. These results revealed that 2 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 value less than 20.0 μM and provided a scientific basis for further processing and utilization of P. foetida.