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<p>A novel class of isoaurone analogs was designed, synthesized, and investigated <i>in vivo</i> for their anti-inammatory activity using a xylene-induced ear edema model. Isoaurones <b>8a–e</b> exhibited anti-inflammatory activity at a dose of 100 mg/kg with inhibition rates ranging from 21.75% to 34.46%. 3-(4-(3-((5-(3-Chlorophenyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)propoxy)benzylidene)-6-methoxybenzofuran-2(3<i>H</i>)-one (<b>8e</b>) showed the most potent growth inhibitory effects (34.46%), indicated by the slightly higher inhibitory effects of celecoxib (31.92%).</p>

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Synthesis and Biological Evaluation of Isoaurone Derivatives as Anti-Inflammatory Agents

  • 期刊论文

  • 发表日期：

    2025年7月19日

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  • Fei Yu,
  • Zhe Liu,
  • Yuan Song,
  • Jinfeng Zhang,
  • Yongsheng Bi,
  • Dianzhuo Jiang

摘要

A novel class of isoaurone analogs was designed, synthesized, and investigated in vivo for their anti-inammatory activity using a xylene-induced ear edema model. Isoaurones 8a–e exhibited anti-inflammatory activity at a dose of 100 mg/kg with inhibition rates ranging from 21.75% to 34.46%. 3-(4-(3-((5-(3-Chlorophenyl)-4H-1,2,4-triazol-3-yl)thio)propoxy)benzylidene)-6-methoxybenzofuran-2(3H)-one (8e) showed the most potent growth inhibitory effects (34.46%), indicated by the slightly higher inhibitory effects of celecoxib (31.92%).