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<p>The compositions of nine fucoidan fractions from five species of brown alga, i.e., AbF from <i>Arthrothamnus bifidus</i>, AkF1 and AkF2 from <i>A. kurilensis</i>, CfF1 and CfF2 from <i>Cymathaere fibrosa</i>, CjF1 and CjF2 from <i>C. japonica</i>, and CtF1 and CtF2 from <i>C. triplicata</i> were studied. The main chains of AbF, AkF2, CfF2, CjF2, and CtF2 were constructed from 1,3-bound <i>α</i>-L-fucose. The studied polysaccharides were nontoxic at concentrations up to 400 μg/mL and exhibited weak inhibitory activity and pronounced inhibitory activity in combination with 2-deoxy-D-glucose on colony formation of SK-MEL-5 melanoma cells.</p>

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Structural Characteristics of Fucoidans from Brown Algae of the Genera Arthrothamnus and Cymathaere and their Metabolically Oriented Action on Colony Formation of SK-MEL-5 Melanoma Cells

  • 期刊论文

  • 发表日期：

    2025年7月19日

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  • N. M. Shevchenko,
  • V. V. Surits,
  • R. V. Usoltseva,
  • A. S. Silchenko,
  • A. O. Zueva,
  • R. A. Shkrabov,
  • O. S. Malyarenko,
  • S. P. Ermakova

摘要

The compositions of nine fucoidan fractions from five species of brown alga, i.e., AbF from Arthrothamnus bifidus, AkF1 and AkF2 from A. kurilensis, CfF1 and CfF2 from Cymathaere fibrosa, CjF1 and CjF2 from C. japonica, and CtF1 and CtF2 from C. triplicata were studied. The main chains of AbF, AkF2, CfF2, CjF2, and CtF2 were constructed from 1,3-bound α-L-fucose. The studied polysaccharides were nontoxic at concentrations up to 400 μg/mL and exhibited weak inhibitory activity and pronounced inhibitory activity in combination with 2-deoxy-D-glucose on colony formation of SK-MEL-5 melanoma cells.