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<p>A new cyclic dipeptide cyclo (L-Pro-D-Trp) <b>1</b>, along with the known compound cyclo (L-Pro-L-Trp) <b>2</b> (brevianamide F), was identified from the rare actinobacterium <i>Crossiella cryophilis</i> CGMCC 4.1710. Extensive spectroscopic analysis, including 1D NMR and HR-ESI-MS, were employed to elucidate the structures of these compounds. The absolute configurations of compounds <b>1</b> and <b>2</b> were determined by comparing them with four chemical synthesized standards (cyclo (L-Pro-L-Trp), cyclo (L-Pro-D-Trp), cyclo (D-Pro-L-Trp), and cyclo (D-Pro-D-Trp) using HPLC-HRMS analysis. However, no bioactivities were detected from the bioassay conducted.</p>

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Discovery of New Cyclic Dipeptide from the Rare Actinobacterium Crossiella cryophilis CGMCC 4.1710

  • 期刊论文

  • 发表日期：

    2025年5月17日

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  • Nuo Chen,
  • Ruochang Qin,
  • Liwei Liu,
  • Huamo Wei,
  • Min Wang

摘要

A new cyclic dipeptide cyclo (L-Pro-D-Trp) 1, along with the known compound cyclo (L-Pro-L-Trp) 2 (brevianamide F), was identified from the rare actinobacterium Crossiella cryophilis CGMCC 4.1710. Extensive spectroscopic analysis, including 1D NMR and HR-ESI-MS, were employed to elucidate the structures of these compounds. The absolute configurations of compounds 1 and 2 were determined by comparing them with four chemical synthesized standards (cyclo (L-Pro-L-Trp), cyclo (L-Pro-D-Trp), cyclo (D-Pro-L-Trp), and cyclo (D-Pro-D-Trp) using HPLC-HRMS analysis. However, no bioactivities were detected from the bioassay conducted.