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<p>Transformations of the monoterpenoid (<i>R</i>)-(+)-pulegone into potentially pharmacologically active <i>N</i>-containing compounds using the Prins reaction as the principle were proposed according to the Pass Online program. A study of the cytotoxic properties of the compounds <i>in vitro</i> on tumor and conditionally normal cell lines did not reveal cytotoxic activity on the studied cell lines. Compound <b>4</b> increased the viability of a conditionally normal cell line under oxidative stress with the compound added after H<sub>2</sub>O<sub>2</sub>. The viability of HCT-116 and A549 tumor lines decreased in an oxidative stress model under the influence of compound <b>2</b>.</p>

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Transformations of (R)-(+)-Pulegone into Potentially Pharmacologically Active N-Containing Derivatives Using the Prins Reaction

  • 期刊论文

  • 发表日期：

    2025年5月17日

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  • Sh. M. Okhirov,
  • N. V. Gromiko,
  • E. R. Latypova,
  • A. N. Lobov,
  • D. V. Ishmetova,
  • E. S. Meshcheryakova,
  • L. M. Khalilov,
  • R. F. Talipov

摘要

Transformations of the monoterpenoid (R)-(+)-pulegone into potentially pharmacologically active N-containing compounds using the Prins reaction as the principle were proposed according to the Pass Online program. A study of the cytotoxic properties of the compounds in vitro on tumor and conditionally normal cell lines did not reveal cytotoxic activity on the studied cell lines. Compound 4 increased the viability of a conditionally normal cell line under oxidative stress with the compound added after H2O2. The viability of HCT-116 and A549 tumor lines decreased in an oxidative stress model under the influence of compound 2.