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<p>A new lasiodiplodin derivative, lasiodiplodin ether (<b>1</b>), along with three known compounds, barceloneic acid A (<b>2</b>), pestalotiopyrone D (<b>3</b>), and 6-hydroxymellein (<b>4</b>), were isolated from the marine fungus <i>Aspergillus clavatus</i> R7. The structure of compound <b>1</b> was deduced by analysis of comprehensive spectra. Compound <b>1</b> showed strong antifungal activity against <i>Fusarium oxysporum</i>, which was equal to triadimefon, and moderate antibacterial activity against <i>Escherichia coli</i> (serotypes O6 and O78). Compounds <b>2</b> and <b>3</b> showed a slightly lesser antifungal effect against <i>Colletotrichum musae</i> than triadimefon.</p>

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A New Lasiodiplodin Derivative from a Marine Fungus Aspergillus clavatus R7

  • 期刊论文

  • 发表日期：

    2025年5月19日

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  • Yaqing Li,
  • Ziyang Li,
  • Zhiyao Feng,
  • Qihua Li,
  • Jiajun Guo,
  • Chunyuan Li,
  • Weijia Ding

摘要

A new lasiodiplodin derivative, lasiodiplodin ether (1), along with three known compounds, barceloneic acid A (2), pestalotiopyrone D (3), and 6-hydroxymellein (4), were isolated from the marine fungus Aspergillus clavatus R7. The structure of compound 1 was deduced by analysis of comprehensive spectra. Compound 1 showed strong antifungal activity against Fusarium oxysporum, which was equal to triadimefon, and moderate antibacterial activity against Escherichia coli (serotypes O6 and O78). Compounds 2 and 3 showed a slightly lesser antifungal effect against Colletotrichum musae than triadimefon.