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<p>Two new pyrroloisoquinolines, 6-methoxy-3-methyl-5,10-dihydropyrrolo[1,2-<i>b</i>]isoquinolin-7-ol (<b>1</b>) and 6,8-dimethoxy-3-methyl-5,10-dihydropyrrolo[1,2-<i>b</i>]isoquinoline (<b>2</b>), together with five known pyrroloisoquinolines (<b>3–7</b>) were isolated from the <i>Nicotiana tabacum</i>-derived endophytic fungus <i>Aspergillus puniceus</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds <b>1</b> and <b>2</b> were tested for their anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity. The results showed that compounds <b>1</b> and <b>2</b> exhibited potential anti-SARS-CoV-2 activity with IC<sub>50</sub> of 16.2 μM and 19.4 μM for the Delta strain and 20.8 μM for the Omicron BA.1 strain, respectively. In addition, the anti-fungi activity test revealed that compounds <b>1</b> and <b>2</b> showed obvious anti-<i>Gibberella cichoracearum</i> (DC.) (the main pathogen of tobacco powdery mildew disease) activity with an inhibition rate of 56.8% ± 4.8 and 62.4% ± 5.2 compared with the negative control, respectively.</p>

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Pyrroloisoquinolines from Nicotiana tabacum Derived Endophytic Fungus Aspergillus puniceus and its Bioactivity

  • 期刊论文

  • 发表日期：

    2025年3月25日

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  • Li-Ying Yang,
  • Yi Li,
  • Gui-Feng Li,
  • Gui-Juan Zhao,
  • Pei-Song Yang

摘要

Two new pyrroloisoquinolines, 6-methoxy-3-methyl-5,10-dihydropyrrolo[1,2-b]isoquinolin-7-ol (1) and 6,8-dimethoxy-3-methyl-5,10-dihydropyrrolo[1,2-b]isoquinoline (2), together with five known pyrroloisoquinolines (3–7) were isolated from the Nicotiana tabacum-derived endophytic fungus Aspergillus puniceus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity. The results showed that compounds 1 and 2 exhibited potential anti-SARS-CoV-2 activity with IC50 of 16.2 μM and 19.4 μM for the Delta strain and 20.8 μM for the Omicron BA.1 strain, respectively. In addition, the anti-fungi activity test revealed that compounds 1 and 2 showed obvious anti-Gibberella cichoracearum (DC.) (the main pathogen of tobacco powdery mildew disease) activity with an inhibition rate of 56.8% ± 4.8 and 62.4% ± 5.2 compared with the negative control, respectively.