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<p>A new amide derivative, cuscujaponamide (<b>1</b>), has been isolated from the aerial parts of <i>Cuscuta japonica</i> var. <i>formosana</i>, together with eight known compounds, kaempferol (<b>2</b>), quercetin (<b>3</b>), astragalin (<b>4</b>), hyperoside (<b>5</b>), (+)-pinoresinol (<b>6</b>), (+)-sesamin (<b>7</b>), caffeic acid (<b>8</b>), and <i>p</i>-coumaric acid (<b>9</b>). The structure of the new compound <b>1</b> was determined through spectroscopic and MS analyses. Among the isolates, cuscujaponamide (<b>1</b>), kaempferol (<b>2</b>), hyperoside (<b>5</b>), and (+)-pinoresinol (<b>6</b>) showed potent inhibition with IC<sub>50</sub> values of 16.03 ±1.46, 18.52 ± 1.70, 18.17 ± 1.64, and 15.90 ± 2.04 μM, respectively, against LPS-induced NO generation. In addition, compounds <b>1</b>, <b>2</b>, <b>3</b>, and <b>5</b> also showed potent DPPH radicals scavenging activities with IC<sub>50</sub> values of 17.29 ± 1.63, 19.02 ± 2.14, 15.62 ±1.42, and 13.25 ±1.45 μM, respectively.</p>

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Anti-Inflammatory and Antioxidant Constituents from Cuscuta japonica var. formosana

  • 期刊论文

  • 发表日期：

    2025年3月26日

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  • Li-Chai Chen,
  • Chien-Ming Huang,
  • Zih-Rong Chen,
  • Chia-Ching Liaw,
  • Ming-Jen Cheng,
  • Jen-Wen Hsiao,
  • Jih-Jung Chen

摘要

A new amide derivative, cuscujaponamide (1), has been isolated from the aerial parts of Cuscuta japonica var. formosana, together with eight known compounds, kaempferol (2), quercetin (3), astragalin (4), hyperoside (5), (+)-pinoresinol (6), (+)-sesamin (7), caffeic acid (8), and p-coumaric acid (9). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, cuscujaponamide (1), kaempferol (2), hyperoside (5), and (+)-pinoresinol (6) showed potent inhibition with IC50 values of 16.03 ±1.46, 18.52 ± 1.70, 18.17 ± 1.64, and 15.90 ± 2.04 μM, respectively, against LPS-induced NO generation. In addition, compounds 1, 2, 3, and 5 also showed potent DPPH radicals scavenging activities with IC50 values of 17.29 ± 1.63, 19.02 ± 2.14, 15.62 ±1.42, and 13.25 ±1.45 μM, respectively.