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<p>The cultured mycobiont of the Vietnamese crustose lichen <i>Diorygma</i> sp. was subjected to chemical investigation, which led to the isolation and characterization of a new guaiane sesquiterpene, diorygmone F (<b>1</b>), along with three known compounds, pruinosone, <i>β</i>-sitosterol, and methyl 4-hydroxybenzoate. Structural elucidation was achieved through extensive spectroscopic methods, including NMR, HR-ESI-MS, and ECD. Compound <b>1</b> displayed modest inhibitory activity against <i>α</i>-glucosidase, with an IC<sub>50</sub> value of 131 ± 1.4 μM, and showed no cytotoxicity against the HepG2 cancer cell line.</p>

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A New Guaiane Sesquiterpene from the Cultured Lichen Mycobiont of Diorygma sp.

  • 期刊论文

  • 发表日期：

    2025年3月27日

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  • Nguyen-Hong-Nhi Phan,
  • Thuc-Huy Duong,
  • Huy Truong Nguyen,
  • Thi-Hoai-Thu Nguyen,
  • Ngoc-Hong Nguyen,
  • Thi-Phi-Giao Vo,
  • Thi-Minh-Dinh Tran,
  • Jirapast Sichaem

摘要

The cultured mycobiont of the Vietnamese crustose lichen Diorygma sp. was subjected to chemical investigation, which led to the isolation and characterization of a new guaiane sesquiterpene, diorygmone F (1), along with three known compounds, pruinosone, β-sitosterol, and methyl 4-hydroxybenzoate. Structural elucidation was achieved through extensive spectroscopic methods, including NMR, HR-ESI-MS, and ECD. Compound 1 displayed modest inhibitory activity against α-glucosidase, with an IC50 value of 131 ± 1.4 μM, and showed no cytotoxicity against the HepG2 cancer cell line.