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<p>A new phenylpropanoid derivative, 1-(2-hydroxy-4-(hydroxymethyl)phenyl)propane-1,2-dione (<b>1</b>), has been isolated from the roots of <i>Eupatorium amabile</i>, together with seven known compounds, 10-acetoxy-8-hydroxy-9-O-angeloylthymol (<b>2</b>), 9-acetoxy-8,10-epoxythymol 3-O-tiglate (<b>3</b>), 9-angeloyloxythymol (<b>4</b>), 9-O-angeloyl-8,10-dehydrothymol (<b>5</b>), rutin (<b>6</b>), eupatorin (<b>7</b>), and coumarin (<b>8</b>). The structure of new compound <b>1</b> was determined through spectroscopic and MS analyses. Among the isolated compounds, compounds <b>1</b>, <b>2</b>, <b>4</b>, and <b>6</b> showed potent inhibition with IC<sub>50</sub> values of 27.69 ± 2.73, 25.02 ± 3.07, 19.18 ± 1.64, and 10.05 ± 0.78 mM, respectively, against LPS-induced NO generation.</p>

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New Phenylpropanoid Derivative and Anti-Inflammatory Constituents from Eupatorium amabile

  • 期刊论文

  • 发表日期：

    2025年3月26日

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  • Ching-Ju Hung,
  • Zih-Rong Chen,
  • Chien-Liang Lin,
  • Tsung-Hsien Chang,
  • Ming-Jen Cheng,
  • Jih-Jung Chen

摘要

A new phenylpropanoid derivative, 1-(2-hydroxy-4-(hydroxymethyl)phenyl)propane-1,2-dione (1), has been isolated from the roots of Eupatorium amabile, together with seven known compounds, 10-acetoxy-8-hydroxy-9-O-angeloylthymol (2), 9-acetoxy-8,10-epoxythymol 3-O-tiglate (3), 9-angeloyloxythymol (4), 9-O-angeloyl-8,10-dehydrothymol (5), rutin (6), eupatorin (7), and coumarin (8). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, compounds 1, 2, 4, and 6 showed potent inhibition with IC50 values of 27.69 ± 2.73, 25.02 ± 3.07, 19.18 ± 1.64, and 10.05 ± 0.78 mM, respectively, against LPS-induced NO generation.