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<p>In this study, two new naphtho[2,3-<i>b</i>]furans (<b>1</b> and <b>2</b>), together with five known naphthalene analogues (<b>3–7</b>), were isolated from the dry distillation products of tobacco stem bark. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds <b>1</b> and <b>2</b> were evaluated for their antibacterial activities against five pathogenic strains (<i>Staphylococcus aureus</i> (SEA), <i>Escherichia coli</i> (EPEC), <i>Streptococcus pyogenes</i> (GAS), <i>Bacillus subtilis</i> (QST713), and <i>Proteus</i> spp.). Interestingly, compounds <b>1</b> and <b>2</b> exhibited notable antibacterial activity with a bacteriostatic diameter in the range of 17.0 ± 1.6–25.8 ± 2.5 mm against the above strains, while most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for <b>1</b> and <b>2</b> used as an antiseptic agent were also evaluated, indicating that they have potential value for use as an antiseptic agent for cigarette tipping paper.</p>

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Two New Antibacterial Naphtho[2,3-b]Furans from the Dry Distillation Products of Tobacco Stem Bark

  • 期刊论文

  • 发表日期：

    2025年3月24日

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  • Yuan-Dong Li,
  • Jian Mei,
  • Yan-Qing Duan,
  • Jin Wang,
  • Jian-Duo Zhang,
  • Jin Li,
  • Heng Wu,
  • Qiu-Fen Hu,
  • Ju-Xing Jiang,
  • Hua-Yin Liu

摘要

In this study, two new naphtho[2,3-b]furans (1 and 2), together with five known naphthalene analogues (3–7), were isolated from the dry distillation products of tobacco stem bark. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were evaluated for their antibacterial activities against five pathogenic strains (Staphylococcus aureus (SEA), Escherichia coli (EPEC), Streptococcus pyogenes (GAS), Bacillus subtilis (QST713), and Proteus spp.). Interestingly, compounds 1 and 2 exhibited notable antibacterial activity with a bacteriostatic diameter in the range of 17.0 ± 1.6–25.8 ± 2.5 mm against the above strains, while most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for 1 and 2 used as an antiseptic agent were also evaluated, indicating that they have potential value for use as an antiseptic agent for cigarette tipping paper.