<p>Two new aromatic sesquiterpenes, nicosesquites C and D (<b>1</b> and <b>2</b>), as well as five known sesquiterpenes (<b>3–7</b>), were isolated from tobacco flower extract. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> were tested for their antibacterial activity against five pathogenic strains (<i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Streptococcus pyogenes</i>, <i>Bacillus subtilis</i>, and <i>Proteus</i> spp.). The results revealed that both compounds showed high antibacterial activity with bacteriostatic diameters in the range of 18.2 ± 1.4~25.8 ± 2.2 mm, respectively. In addition, compounds <b>1</b> and <b>2</b> also have a weak resin-like aroma, and they have potential value for use as an essence for cigarettes.</p>

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Two New Aromatic Sesquiterpenes from Tobacco Flower Extract and Their Antibacterial Activity

  • Xin-Yao Huang,
  • Jin-Yun Liu,
  • Jin Wang,
  • Li-Ying Yang,
  • Chong-Jun Xu,
  • Kua-Ping Wang,
  • Guang-Yu Yang,
  • Qiu-Fen Hu,
  • Shi-Tao Xu,
  • Hua-Yin Liu

摘要

Two new aromatic sesquiterpenes, nicosesquites C and D (1 and 2), as well as five known sesquiterpenes (3–7), were isolated from tobacco flower extract. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their antibacterial activity against five pathogenic strains (Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Bacillus subtilis, and Proteus spp.). The results revealed that both compounds showed high antibacterial activity with bacteriostatic diameters in the range of 18.2 ± 1.4~25.8 ± 2.2 mm, respectively. In addition, compounds 1 and 2 also have a weak resin-like aroma, and they have potential value for use as an essence for cigarettes.