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<p>A new naphtho[2,3-c]furan-1(3H)-one derivative, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (<b>1</b>), has been isolated from the stem bark of <i>Rhamnus kanagusukii</i>, together with eight known compounds, chrysophanol (<b>2</b>), emodin (<b>3</b>), rhamnazin (<b>4</b>), kaempferol (<b>5</b>), apigenin (<b>6</b>), taxifolin (<b>7</b>), ferulic acid (<b>8</b>), and gallic acid (<b>9</b>). The structure of new compound <b>1</b> was determined using spectroscopic and MS analyses. Among the isolated compounds, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (<b>1</b>), kaempferol (<b>5</b>), apigenin (<b>6</b>), and taxifolin (<b>7</b>) showed potent inhibition with IC<sub>50</sub> values of 19.48 ± 1.52, 20.48 ± 1.84, 16.47 ± 1.25, and 15.44 ± 1.02 μM, respectively, against LPS-induced NO generation. In addition, compounds <b>5</b>, <b>6</b>, <b>7</b>, <b>8</b>, and <b>9</b> also showed potent DPPH radical scavenging activities with IC<sub>50</sub> values of 21.11 ± 1.84, 22.47 ± 2.04, 13.02 ± 1.07, 14.54 ± 1.35, and 13.48 ± 1.16 μM respectively.</p>

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A New Naphtho[2,3-c]Furan-1(3H)-One Derivative and Anti-Inflammatory and Antioxidant Constituents from Rhamnus kanagusukii

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • Chu-Wen Kuo,
  • Zih-Rong Chen,
  • Hsueh-Yang Huang,
  • Chia-Ching Liaw,
  • Ping-Jyun Sung,
  • Ming-Jen Cheng,
  • Fu-Sen Wu,
  • Jih-Jung Chen

摘要

A new naphtho[2,3-c]furan-1(3H)-one derivative, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (1), has been isolated from the stem bark of Rhamnus kanagusukii, together with eight known compounds, chrysophanol (2), emodin (3), rhamnazin (4), kaempferol (5), apigenin (6), taxifolin (7), ferulic acid (8), and gallic acid (9). The structure of new compound 1 was determined using spectroscopic and MS analyses. Among the isolated compounds, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (1), kaempferol (5), apigenin (6), and taxifolin (7) showed potent inhibition with IC50 values of 19.48 ± 1.52, 20.48 ± 1.84, 16.47 ± 1.25, and 15.44 ± 1.02 μM, respectively, against LPS-induced NO generation. In addition, compounds 5, 6, 7, 8, and 9 also showed potent DPPH radical scavenging activities with IC50 values of 21.11 ± 1.84, 22.47 ± 2.04, 13.02 ± 1.07, 14.54 ± 1.35, and 13.48 ± 1.16 μM respectively.