Scholarlink

<p>One new coumaronochromone named 5,7,2′-trihydroxy-6-methoxycoumaronochromone (<b>1</b>), and six known compounds named benzyl-<i>O</i>-<i>α</i>-L-rhamnopyranosyl-(1→6)-<i>β</i>-D-glucopyranoside (<b>2</b>), chikusetsusaponin V (<b>3</b>), crotonine (<b>4</b>), ayamenin A (<b>5</b>), achyranthoside A (<b>6</b>), 5-hydroxypyridine-2-carboxylic acid methyl ester (<b>7</b>), were obtained from <i>Achyranthes bidentata</i>. The antihyperuricemic acid activities of these isolated compounds (<b>1–7</b>) were assayed by an HK-2 cell model induced by adenosine combined with xanthine oxidase. The contents of uric acid produced by the HK-2 cell model were determined by HPLC analysis. As the results show, compound <b>3</b> was the most effective and was almost in line with the positive drug of febuxostat, whereas compounds <b>1</b>, <b>4</b>, <b>5</b>, and <b>6</b> showed moderate antihyperuricemic acid activities at a concentration of 50.0 μM.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Chemical Constituents from Achyranthes bidentata and Their Antihyperuricemic Acid Activities

  • 期刊论文

  • 发表日期：

    2025年1月1日

查看全文
  • Jinqian Yu,
  • Xiao Wang,
  • E. Kh. Botirov,
  • Hongjing Dong,
  • S. D. Gusakova,
  • Wei Liu

摘要

One new coumaronochromone named 5,7,2′-trihydroxy-6-methoxycoumaronochromone (1), and six known compounds named benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (2), chikusetsusaponin V (3), crotonine (4), ayamenin A (5), achyranthoside A (6), 5-hydroxypyridine-2-carboxylic acid methyl ester (7), were obtained from Achyranthes bidentata. The antihyperuricemic acid activities of these isolated compounds (1–7) were assayed by an HK-2 cell model induced by adenosine combined with xanthine oxidase. The contents of uric acid produced by the HK-2 cell model were determined by HPLC analysis. As the results show, compound 3 was the most effective and was almost in line with the positive drug of febuxostat, whereas compounds 1, 4, 5, and 6 showed moderate antihyperuricemic acid activities at a concentration of 50.0 μM.