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<p>Twenty-six compounds, including one new 2-(2-phenylethyl)chromone derivative, (<i>R</i>)-2-(1-hydroxy-2- phenylethyl)chromone (<b>1</b>), and one new resorcylic acid lactone, (<i>S</i>)-de-O-methylhispidulactone A (<b>2</b>), were isolated from the nonresinous heartwood of <i>Aqualaria sinensis</i> (Lour.) Spreng. Among these compounds, (<i>S</i>)-de-<i>O</i>-methylhispidulactone A (<b>2</b>), 2-(2-phenylethyl)chromone (<b>4</b>), 2-[2-(4-hydroxyphenyl)ethyl]chromone (<b>7</b>), 6-methoxy-2-(2-phenylethyl)chromone (<b>8</b>), 6-methoxy-2-[2-(3-methoxyphenyl)ethyl]chromone (<b>9</b>), 2-[2-(3-methoxyphenyl)ethyl]chromone (<b>10</b>), 6,7-dimethoxy-2-(2-phenylethyl)chromone (<b>11</b>), 8-chloro-6- hydroxy-2-[2-(4-methoxyphenyl)ethyl]chromon-4-one (<b>13</b>), (+)-(<i>R</i>)-de-<i>O</i>-methyllasiodiplodin (<b>14</b>), lasiodiplodin (<b>15</b>), and (3<i>R</i>)-(–)-melliein (<b>20</b>) exhibited antifungal activity against <i>Epidermophyton floccosum</i>, <i>Trichophyton rubrum</i>, and <i>Microsporum gypseum</i>, with MIC values ranging from 5.8 to 51.6 μM. Furthermore, (<i>R</i>)-2-(2-hydroxy-2-phenylethyl)chromone (<b>3b</b>), <b>7</b>, <b>8</b>, <b>9</b>, <b>14, 15</b>, 5-hydroxy-7,3′,4′- trimethoxyflavone (<b>17</b>), and velutin (<b>18</b>) demonstrated antibacterial effects against <i>Staphylococcus aureus</i>, with MIC values ranging from 20.2 to 96.0 μM.</p>

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Chemical Constituents and Antimicrobial Properties of the Nonresinous Heartwood of Aquilaria sinensis

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • Xiao-Yan Duan,
  • Dong-Bao Hu,
  • Hataichanok Pandith,
  • Terd Disayathanoowat,
  • Xue Bai,
  • Jun Yang,
  • Ji-Feng Luo,
  • Angkhana Inta,
  • Yue-Hu Wang

摘要

Twenty-six compounds, including one new 2-(2-phenylethyl)chromone derivative, (R)-2-(1-hydroxy-2- phenylethyl)chromone (1), and one new resorcylic acid lactone, (S)-de-O-methylhispidulactone A (2), were isolated from the nonresinous heartwood of Aqualaria sinensis (Lour.) Spreng. Among these compounds, (S)-de-O-methylhispidulactone A (2), 2-(2-phenylethyl)chromone (4), 2-[2-(4-hydroxyphenyl)ethyl]chromone (7), 6-methoxy-2-(2-phenylethyl)chromone (8), 6-methoxy-2-[2-(3-methoxyphenyl)ethyl]chromone (9), 2-[2-(3-methoxyphenyl)ethyl]chromone (10), 6,7-dimethoxy-2-(2-phenylethyl)chromone (11), 8-chloro-6- hydroxy-2-[2-(4-methoxyphenyl)ethyl]chromon-4-one (13), (+)-(R)-de-O-methyllasiodiplodin (14), lasiodiplodin (15), and (3R)-(–)-melliein (20) exhibited antifungal activity against Epidermophyton floccosum, Trichophyton rubrum, and Microsporum gypseum, with MIC values ranging from 5.8 to 51.6 μM. Furthermore, (R)-2-(2-hydroxy-2-phenylethyl)chromone (3b), 7, 8, 9, 14, 15, 5-hydroxy-7,3′,4′- trimethoxyflavone (17), and velutin (18) demonstrated antibacterial effects against Staphylococcus aureus, with MIC values ranging from 20.2 to 96.0 μM.