Synthesis of New Carbamates of the Alkaloid Songorine and Their Effects on Cancer Cell Growth

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发表日期：

2024年11月9日

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U. Kh. Kurbanov,
N. I. Mukarramov,
E. O. Terenteva,
U. B. Khamidova,
O. T. Juraev,
Sh. S. Azimova

摘要

Six new derivatives were synthesized by reacting the alkaloid songorine (1) with isocyanates. Their structures were confirmed by IR, mass, ¹H and ¹³C NMR spectral methods. The effects of the obtained compounds on tumor cell growth in vitro were studied. 21-Ethyl-1-O-3′-chlorophenylcarbamate-15-hydroxy-4-methyl-16-methylene-7,20-cycloveatchan-12-one (3c) exhibited cytotoxicity against HeLa and HEp-2 lines at a concentration of 100 μg/mL. The other songorine derivatives caused dose-dependent proliferation of cancer cells.