Synthesis and Cytotoxicity Against M-HeLa, HuTu 80, and MCF-7 Human Cancer Cells of the First Nucleoterpenoids of the Isosteviol Diterpenoid Platform

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发表日期：

2024年11月13日

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O. V. Andreeva,
M. G. Belenok,
I. Yu. Strobykina,
L. F. Saifina,
A. P. Lyubina,
A. S. Sapunova,
A. D. Voloshina,
B. F. Garifullin,
V. E. Semenov,
V. E. Kataev

摘要

Conjugates of the diterpenoid isosteviol with uracil and 6-methyluracil (nucleoterpenoids) were synthesized and showed moderate in vitro cytotoxicity (IC₅₀ values in the range 11.6–51.0 μM) against M-HeLa, HuTu 80, and MCF-7 human cancer cells.