Synthesis and Antiviral Activity of Mannich Bases of Dehydroquinopimaric Acid and Maleopimaric Acid Alkyl Derivatives
摘要
New aminomethyl diterpenoids were synthesized by Cu(I)-catalyzed Mannich reactions of maleopimaric acid or 1a,4a-dehydroquinopimaric acid alkyl derivatives, amines, and paraformaldehyde. Studies of the antiviral activity of the synthesized compounds showed that C20-modified Mannich bases of the propargyl ester and propargylamide of maleopimaric acid had the highest activity against influenza A virus (H1N1) with therapeutic indices SI 31-49.