A New Antibacterial Indole Alkaloid from Cigar Tobacco and Its Potential Application in Antiseptic Cigarette Tipping Paper
摘要
A new indole alkaloid, cigarindole A (1), together with five known indole alkaloids (2–6) were isolated from cigar tobacco. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Interestingly, compound 1 exhibited high antibacterial activity with bacteriostatic diameter within the range 20.6–26.7 mm against five pathogenic strains (Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Bacillus subtilis, and Proteus spp). Compounds 2–6 exhibited obvious antibacterial activity with bacteriostatic diameter within the range 11.9–21.8 mm. In addition, compound 1 also the potential value for use as an antiseptic agent for cigarette tipping paper.