New Isoflavonoid and Anti-Inflammatory Constituents from Myristica elliptica var. simiarum
摘要
A new isoflavone, 4′-hydroxy-5,7,2′-trimethoxyisoflavone (1), has been isolated from the fruits of Myristica elliptica var. simiarum, together with seven known compounds, 2′-hydroxygenistein (2), licarin A (3), accuminatin (4), guaiacin (5), virolane (6), elimicin (7), and β-sitosterol (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, 4′-hydroxy-5,7,2′-trimethoxyisoflavone (1), 2′-hydroxygenistein (2), licarin A (3), and guaiacin (5) showed potent inhibition with IC50 values of 24.18 ± 2.09, 16.39 ± 1.26, 22.68 ± 2.30, and 27.01 ± 2.42 μM, respectively, against LPS-induced NO generation.