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Prenylated Flavonoids from Desmodium caudatum and as Potential Activators for SARS-CoV-2

  • Gui-Juan Zhao,
  • Min Yang,
  • Yan-Qun Zhang,
  • Gui-Feng Li,
  • Gui Pu,
  • Sui Yao,
  • Dong Miao,
  • Yin-Ke Li,
  • Qiu-fen Hu,
  • Xin-Zhou Yang

摘要

Two new isoprenylated flavone, 8,4′-dimethoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone (1), 8-hydroxy-4′-methoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone (2), together with seven known isoprenylated flavonoids (3–9) were isolated from the whole plants of Desmodium caudatum. Their structures were established by their 1D, 2D NMR, and MS spectral data. In addition, compounds 1–9 were tested for their anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity.