Synthesis and Anti-VIBRIO Activity of Gallic Acid Derivatives Containing Thiosemicarbazide
摘要
In order to explore new gallic acid derivatives with high antibacterial activity, we synthesize a series of new 1-(3,4,5-trihydroxybenzoyl)-4-(substituted benzoyl)thiosemicarbazide and evaluate their activities against Vibrio harveyi, Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus in vitro. Through the experiments, we found that compound 7d has the best inhibitory activity against V. harveyi and V. cholerae, the minimum inhibitory concentration (MIC) values were 0.0078 mg/mL and 0.0156 mg/mL; compound 7h has the best inhibitory activity against V. parahaemolyticus and V. vulnificus, with MIC values of 0.0313 mg/mL and 0.0625 mg/mL.