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<p></p><p>5-Chloro-4-formylpyrrole-3-carboxylates and carboxylic acids can smoothly interact with thiazolidin-4-ones and form 5-chloro-4-[(thiazolidin-5-ylidene)methyl]pyrrole-3-carboxylates and carboxylic acids, respectively, which can further be transformed into thieno-[2,3-<i>b</i>]pyrrole-2,4-dicarboxylic acids through the alkaline hydrolysis. Moderate antimicrobial activity has been registered in 5-chloro-4-[(thiazolidin-5-ylidene)methyl]pyrrole-3-carboxylates and the corresponding carboxylic acids.</p>

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5-Chloro-4-[(thiazolidin-5-ylidene)methyl]pyrrole-3-carboxylates and carboxylic acids: synthesis, recycling, and antimicrobial activity

  • 期刊论文

  • 发表日期：

    2026年5月30日

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  • Alina M. Grozav,
  • Mariana Z. Fedoriv,
  • Vitaliy O. Chornous,
  • Sergiy V. Kemskyi,
  • Nina D. Yakovychuk,
  • Oleksandr S. Liavynets,
  • Mykhailo V. Vovk

摘要

5-Chloro-4-formylpyrrole-3-carboxylates and carboxylic acids can smoothly interact with thiazolidin-4-ones and form 5-chloro-4-[(thiazolidin-5-ylidene)methyl]pyrrole-3-carboxylates and carboxylic acids, respectively, which can further be transformed into thieno-[2,3-b]pyrrole-2,4-dicarboxylic acids through the alkaline hydrolysis. Moderate antimicrobial activity has been registered in 5-chloro-4-[(thiazolidin-5-ylidene)methyl]pyrrole-3-carboxylates and the corresponding carboxylic acids.