Scholarlink

<p></p><p>An efficient, environmentally friendly protocol was developed for the synthesis of 4-substituted 1,5-benzodiazepines <i>via</i> a one-pot threecomponent reaction. <i>o</i>-Phenylenediamines, dimedone, and aldehydes were reacted in the presence of silica-supported orthophosphoric acid (H<sub>3</sub>PO<sub>4</sub>·SiO<sub>2</sub>) as an environmentally friendly, heterogeneous catalyst at 70°C to produce 4-substituted 1,5-benzodiazepines. High to excellent yields, metal-free, environmentally friendly, reusable catalyst, and faster reactivity are the notable features of the developed protocol.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Silica-supported orthophosphoric acid (H3PO4·SiO2) as an environmentally friendly, heterogeneous catalyst for one-pot synthesis of 4-substituted 1,5-benzodiazepines

  • 期刊论文

  • 发表日期：

    2026年5月13日

查看全文
  • Minal S. Kattimani,
  • Poonam H. Khyadage,
  • Satish D. Mitragotri,
  • Makarand A. Kulkarni,
  • Prakash P. Wadgaonkar

摘要

An efficient, environmentally friendly protocol was developed for the synthesis of 4-substituted 1,5-benzodiazepines via a one-pot threecomponent reaction. o-Phenylenediamines, dimedone, and aldehydes were reacted in the presence of silica-supported orthophosphoric acid (H3PO4·SiO2) as an environmentally friendly, heterogeneous catalyst at 70°C to produce 4-substituted 1,5-benzodiazepines. High to excellent yields, metal-free, environmentally friendly, reusable catalyst, and faster reactivity are the notable features of the developed protocol.