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<p></p><p>The double Michael addition reaction is a highly effective approach for constructing spirocyclic compounds, which frequently occur in nature and exhibit biological activity. In this study, the double Michael addition reaction of 7-azaoxindole with dienones was explored using tetrabutylammonium bromide as a catalyst. The target spirocyclic azaoxindoles were obtained in moderate to high yields.</p>

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Efficient construction of spirocyclic azaoxindoles via double Michael addition reaction using phase-transfer catalysis

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Bo Lu,
  • Huilan Zhang,
  • Shuhui Ren,
  • Wenqin Liu,
  • Yan Lin,
  • Pingnan Wan,
  • Hanfeng Cui

摘要

The double Michael addition reaction is a highly effective approach for constructing spirocyclic compounds, which frequently occur in nature and exhibit biological activity. In this study, the double Michael addition reaction of 7-azaoxindole with dienones was explored using tetrabutylammonium bromide as a catalyst. The target spirocyclic azaoxindoles were obtained in moderate to high yields.