Selective reduction of 8-hydroxy-5,7-dinitroquinoline and synthesis of 2-substituted 5-nitrooxazolo[4,5-h]quinolines
摘要
Chemoselective reduction of the ortho-nitro group in 8-hydroxy-5,7-dinitroquinoline was carried out by the action of Na2S in H2O and DMSO as well as by hydrogenation on 0.8% Pd/C. A number of new 2-substituted 5-nitrooxazolo[4,5-h]quinolines were obtained starting from the synthesized 7-amino-5-nitroquinolin-8-ol.