A reaction of aroyl(heteroaroyl)pyruvic acid esters with 3,3-diaminoacrylonitriles: a new method for the synthesis of pyrroles with conjugated exocyclic double bonds
摘要
Pyrroles incorporating conjugated exocyclic C=C and C=O bonds were obtained in the reaction of 3,3-diaminoacrylonitriles with aroyl-(heteroaroyl)pyruvic acid esters. A simple and efficient method for the synthesis of pyrroles was developed based on this reaction, which makes it possible to vary the substituents in positions 1 and 5 of the pyrrole ring and in the 2-oxoethylidene fragment.