<p>Climate change activism is crucial to promoting effective climate change mitigation and adaptation policies. This study examined the relationship between experiencing extreme weather events, the health and well-being impact of extreme weather events among respondents and their household members, and engagement in climate change activism. Survey data were weighted to create a representative sample of U.S. adults (<i>N</i> = 2,646) and assessed exposure to tornadoes, hurricanes or severe tropical storms, extreme heatwaves, wildfires, major flooding, major droughts or water shortages, rising sea levels, and severe cold weather or winter storms. The impacts of these events on the health and well-being of household members were also assessed. Multivariable logistic regression models examined correlates of climate change activism behaviors. Exposure to extreme weather events was common, with a median of two extreme weather events reported over the past five years. More than 10% reported at least one serious health problem in their household. 22.8% of respondents reported engagement in climate change activism. In the multivariable analyses, exposure to six of the seven extreme weather events, as well as extreme weather-related impacts such as serious financial troubles, displacement from one’s home, and major property damage, were significantly associated with engagement in climate change activism. The study results suggest that many U.S. residents have experienced extreme weather events, and that both personal experiences with such events and serious health impacts among respondents or their household members from these events were associated with increased climate change activism.</p>