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<p>The multifunctional roles of alpha7 nicotinic acetylcholine receptors (α7nAChRs), ranging from cognitive enhancement, neuroprotection, and anti-inflammatory action, credit tagging this receptor as “unique” among the cholinergic receptor family. The uniqueness of α7nAChRs in neuronal function and communication lies in their high calcium permeability among the cholinergic receptor family. The ionotropic function of α7nAChRs is governed by protein kinases’ post-translational modification (PTMs), which alter their expression and function, affecting neuronal communication. A decrease in the ionotropic function of α7nAChRs and its downstream signaling pathways is observed across many neurological disorders. The loss of α7nAChRs, decreased cholinergic function, and increased acetylcholinesterase levels are commonly associated with neuronal degeneration, cognitive impairment, and decreased memory function. An extensive body of evidence suggests the cognitive benefits of simple nutraceutical supplementation, Vitamin D3 (VD), in many neurological disorders (Skv et al. in Mol Neurobiol 61:7211–7238, 2024). The present review will, however, focus on recent and past evidence deciphering the unique properties of α7nAChRs crucial for brain function. We have&#xa0;also emphasized on&#xa0;the therapeutic benefits of VD supplementation in restoring cholinergic neurotransmission and α7nAChRs expression in various neuropsychiatric and neurological disorders. </p> Graphical Abstract <p>An overview of the importance and the therapeutic potential of α7nAChRs. α7nAChRs play a pivotal role in the maintenance of synaptic plasticity, cognitive enhancement, and neuroprotection. α7nAChR’s activation or restoration results in enhanced memory, cognitive restoration, anti-inflammatory effects, and neuroprotection in neuropathological states.</p> <p></p>

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Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月16日

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  • Sharon Mariam Abraham,
  • Sneha Suresh,
  • Pragya Komal

摘要

The multifunctional roles of alpha7 nicotinic acetylcholine receptors (α7nAChRs), ranging from cognitive enhancement, neuroprotection, and anti-inflammatory action, credit tagging this receptor as “unique” among the cholinergic receptor family. The uniqueness of α7nAChRs in neuronal function and communication lies in their high calcium permeability among the cholinergic receptor family. The ionotropic function of α7nAChRs is governed by protein kinases’ post-translational modification (PTMs), which alter their expression and function, affecting neuronal communication. A decrease in the ionotropic function of α7nAChRs and its downstream signaling pathways is observed across many neurological disorders. The loss of α7nAChRs, decreased cholinergic function, and increased acetylcholinesterase levels are commonly associated with neuronal degeneration, cognitive impairment, and decreased memory function. An extensive body of evidence suggests the cognitive benefits of simple nutraceutical supplementation, Vitamin D3 (VD), in many neurological disorders (Skv et al. in Mol Neurobiol 61:7211–7238, 2024). The present review will, however, focus on recent and past evidence deciphering the unique properties of α7nAChRs crucial for brain function. We have also emphasized on the therapeutic benefits of VD supplementation in restoring cholinergic neurotransmission and α7nAChRs expression in various neuropsychiatric and neurological disorders.

Graphical Abstract

An overview of the importance and the therapeutic potential of α7nAChRs. α7nAChRs play a pivotal role in the maintenance of synaptic plasticity, cognitive enhancement, and neuroprotection. α7nAChR’s activation or restoration results in enhanced memory, cognitive restoration, anti-inflammatory effects, and neuroprotection in neuropathological states.