Scholarlink

<p>Arthritis is a common disease characterized by joint inflammation, resulting from the interaction of genetic, immunological, and environmental factors. Osteoarthritis is marked by cartilage degeneration, whereas rheumatoid arthritis is characterized by synovial inflammation. Current treatments include pharmacological agents, physical therapy, and surgical interventions; however, these approaches have limited efficacy and may be associated with side effects. Therefore, tissue engineering has emerged as an innovative alternative for the repair of joint damage. In this study, bacterial cellulose (BC), chosen as the primary polymer for its superior mechanical properties, biocompatibility, and high water retention capacity, was combined with polylactic acid (PLA) and poly(3-hydroxybutyrate) (PHB) to design a bilayer scaffold system for bone and cartilage regeneration. To provide antimicrobial protection, vancomycin was incorporated into the nanofiber layer with the aim of achieving controlled release. The developed system supports cell proliferation and extracellular matrix (ECM) synthesis in cartilage tissue while enhancing mechanical strength and promoting osteogenic cell migration in bone tissue. Furthermore, it has the potential to slow cartilage degeneration in osteoarthritis, suppress inflammation in rheumatoid arthritis, and prevent infection-related damage. This integrated approach offers a multifunctional therapeutic platform aimed at complete osteochondral unit regeneration.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sustainable bacterial cellulose-based scaffolds for bone and cartilage regeneration: addressing arthritis-induced tissue damage

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月3日

查看全文
  • Beyza Topcu,
  • Elif Ilhan,
  • Dilek Kazan,
  • Orkun Pinar,
  • Mehmet Mucahit Guncu,
  • Oguzhan Gunduz

摘要

Arthritis is a common disease characterized by joint inflammation, resulting from the interaction of genetic, immunological, and environmental factors. Osteoarthritis is marked by cartilage degeneration, whereas rheumatoid arthritis is characterized by synovial inflammation. Current treatments include pharmacological agents, physical therapy, and surgical interventions; however, these approaches have limited efficacy and may be associated with side effects. Therefore, tissue engineering has emerged as an innovative alternative for the repair of joint damage. In this study, bacterial cellulose (BC), chosen as the primary polymer for its superior mechanical properties, biocompatibility, and high water retention capacity, was combined with polylactic acid (PLA) and poly(3-hydroxybutyrate) (PHB) to design a bilayer scaffold system for bone and cartilage regeneration. To provide antimicrobial protection, vancomycin was incorporated into the nanofiber layer with the aim of achieving controlled release. The developed system supports cell proliferation and extracellular matrix (ECM) synthesis in cartilage tissue while enhancing mechanical strength and promoting osteogenic cell migration in bone tissue. Furthermore, it has the potential to slow cartilage degeneration in osteoarthritis, suppress inflammation in rheumatoid arthritis, and prevent infection-related damage. This integrated approach offers a multifunctional therapeutic platform aimed at complete osteochondral unit regeneration.