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Abstract <p>Bacterial cellulose (BC), a natural biopolymer, exhibits excellent biocompatibility and mechanical properties but lacks inherent antibacterial and hemostatic properties, which hinders its application in wound dressing. In this study, we developed a novel BC-derived hydrogel loaded with nano-silver (AgNPs) and <i>Panax notoginseng</i> (PN) powder (BC@AgNPs/PN) to address these limitations. The hydrogel exhibited exceptional porosity, eco-friendly degradability (33% degradation within 35&#xa0;days), outstanding mechanical strength (52&#xa0;kPa), and water retention capacity (1622%), making it suitable for accommodating various body movements and maintaining a moist environment conducive to wound healing. The hydrogel demonstrated excellent antibacterial properties, achieving 99% and 98% inhibition against <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>), respectively. The incorporation of PN significantly enhanced its hemostatic performance, with a coagulation index of 41%. The hydrogel demonstrated excellent biocompatibility with L929 cells, with cell viability exceeding 85%, highlighting its potential in biomedical applications. Additionally, in vivo studies using a mouse model confirmed its effective promotion of wound healing, with a wound healing rate exceeding 90% within 18&#xa0;days. Overall, the developed BC-derived hydrogel exhibits superior antibacterial activity, efficient hemostatic properties, and excellent biocompatibility, making it a promising candidate for advanced wound dressing applications.</p> Graphical abstract <p></p>

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Bacterial cellulose-based antibacterial and haemostatic hydrogel dressing with nanosilver and Panax notoginseng for enhanced wound healing

  • 期刊论文

  • 发表日期：

    2025年11月8日

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  • Xiaolong Cui,
  • Yatong Yu,
  • Xiaoying Wang,
  • Shoujuan Wang,
  • Chunling Zhang,
  • Fangong Kong,
  • Joe R. Zhao,
  • Pedram Fatehi

摘要

Abstract

Bacterial cellulose (BC), a natural biopolymer, exhibits excellent biocompatibility and mechanical properties but lacks inherent antibacterial and hemostatic properties, which hinders its application in wound dressing. In this study, we developed a novel BC-derived hydrogel loaded with nano-silver (AgNPs) and Panax notoginseng (PN) powder (BC@AgNPs/PN) to address these limitations. The hydrogel exhibited exceptional porosity, eco-friendly degradability (33% degradation within 35 days), outstanding mechanical strength (52 kPa), and water retention capacity (1622%), making it suitable for accommodating various body movements and maintaining a moist environment conducive to wound healing. The hydrogel demonstrated excellent antibacterial properties, achieving 99% and 98% inhibition against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively. The incorporation of PN significantly enhanced its hemostatic performance, with a coagulation index of 41%. The hydrogel demonstrated excellent biocompatibility with L929 cells, with cell viability exceeding 85%, highlighting its potential in biomedical applications. Additionally, in vivo studies using a mouse model confirmed its effective promotion of wound healing, with a wound healing rate exceeding 90% within 18 days. Overall, the developed BC-derived hydrogel exhibits superior antibacterial activity, efficient hemostatic properties, and excellent biocompatibility, making it a promising candidate for advanced wound dressing applications.

Graphical abstract