Scholarlink

<p>Conventional cancer therapies are limited by inadequate tumor targeting, off-target toxicity, and low drug loading efficiency. A novel folic acid-conjugated curcumin-loaded cellulose nanofibers (FA-CU-CNFs) system was developed to address these challenges. Wheat cellulose nanofibers (WCNFs) were synthesized through several processes, including alkaline treatment, acid hydrolysis, and ultrasonication. WCNFs were functionalized with amine groups, loaded with curcumin, and conjugated with folic acid using EDS/NHS coupling. Functionalized WCNFs were characterized using various analyses. Results revealed a particle size of 488.7&#xa0;nm, zeta potential (ZP) of −18.83&#xa0;mV, and Fourier transform infrared (FTIR) spectroscopic bands indicating successful conjugation. In contrast, X-ray Diffraction (XRD) analysis revealed a decrease in crystallinity. FA-CU-CNFs achieved encapsulation and drug-loading efficiencies of 84.37% and 34.71%, respectively. In vitro studies demonstrated pH-responsive drug release, with 85.21% release at pH 6.8 and 64.14% at pH 7.4, respectively. The cytotoxicity against A549 lung cancer cells showed an IC<sub>50</sub> value of 100&#xa0;µM/mL. This nanofiber system represents a promising strategy for the targeted and controlled delivery of curcumin to lung cancer cells.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Innovative fabrication of folic acid-conjugated curcumin cellulose nanofibers for targeted lung cancer therapy

  • 期刊论文

  • 发表日期：

    2025年10月12日

查看全文
  • Vivekanand Chatap,
  • Bhakti Patel,
  • Tejas Patil,
  • Gautam Priyadarshi,
  • Mudassar Shahid,
  • Rabbani Syed,
  • Snehal Bagatharia,
  • Dipak Kumar Sahoo,
  • Ashish Patel

摘要

Conventional cancer therapies are limited by inadequate tumor targeting, off-target toxicity, and low drug loading efficiency. A novel folic acid-conjugated curcumin-loaded cellulose nanofibers (FA-CU-CNFs) system was developed to address these challenges. Wheat cellulose nanofibers (WCNFs) were synthesized through several processes, including alkaline treatment, acid hydrolysis, and ultrasonication. WCNFs were functionalized with amine groups, loaded with curcumin, and conjugated with folic acid using EDS/NHS coupling. Functionalized WCNFs were characterized using various analyses. Results revealed a particle size of 488.7 nm, zeta potential (ZP) of −18.83 mV, and Fourier transform infrared (FTIR) spectroscopic bands indicating successful conjugation. In contrast, X-ray Diffraction (XRD) analysis revealed a decrease in crystallinity. FA-CU-CNFs achieved encapsulation and drug-loading efficiencies of 84.37% and 34.71%, respectively. In vitro studies demonstrated pH-responsive drug release, with 85.21% release at pH 6.8 and 64.14% at pH 7.4, respectively. The cytotoxicity against A549 lung cancer cells showed an IC50 value of 100 µM/mL. This nanofiber system represents a promising strategy for the targeted and controlled delivery of curcumin to lung cancer cells.

Graphical Abstract