<p>Glucose-responsive, antioxidant and antibacterial hydrogels show significant promise in the treatment of diabetic wounds. In this study, we fabricated composite hydrogels with a dual-network structure using cellulose nanofibers (CNFs), tannin (TA), 3-acrylamidophenyl boronic acid (AAPBA), and acrylamide (AM) via chemical and physical crosslinking for potential application as wound dressings. AAPBA was copolymerized with AM using ammonium persulfate (APS) as the initiator and <i>N</i>,<i>N</i>′-methylene-<i>bis</i>-acrylamide (MBA) as the crosslinker. CNFs and tannins are cross-linked with poly(AM–AAPBA) through the formation of dynamic borate ester bonds between the boronic acid groups in AAPBA and the <i>o</i>-dihydroxy groups in tannins and CNFs, as well as the hydrogen bonds among them. The tensile strength increased from 12.6&#xa0;kPa for the neat polyacrylamide (PAM) to a maximum of 43.1&#xa0;kPa for the composite hydrogel. The elasticity and plasticity could be altered by changing the dosage of MBA. The dynamic borate ester bonds within the hydrogels enabled quick self-recovery. The addition of tannins imparted high antioxidant, UV shielding and antimicrobial properties to the hydrogel, which is favourable for its application in biomedical fields. The ability to adsorb bovine serum albumin (BSA) was significantly enhanced, reaching a maximum of 355.6&#xa0;mg/g, enabling effective absorption of tissue fluid exudate from wounds. Tannins were consistently released from the hydrogels, and the amount released was approximately 20% greater in a glucose solution, highlighting their glucose-responsive behaviour, which is valuable in the treatment of diabetic wounds. These glucose-responsive, antioxidant, and antibacterial composite hydrogels have potential applications in the biomedical field.</p> Graphical abstract <p></p>