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<p>Co-substrate fermentation has become an essential approach to achieving high-efficiency and low-cost production of poly (β-<span>l</span>-malic acid) (PMA). Herein, sustainable rubberwood (<i>Hevea brasiliensis</i>) hydrolysate (RWH) was co-fermented by <i>A. pullulans</i> to synthesize PMA using glucose and xylose as co-substrate carbon sources. Moreover, vitamin B was explored as nutrient supplementation in this study. Results showed that compared with the single RWH substrate, the PMA production of co-substrate fermentation increased by 38–52%. Furthermore, the addition of VB<sub>6</sub> promoted the utilization of substrates and shortened the fermentation cycle of PMA. During the scale-up fermentation, the PMA yield reached 0.50–0.54&#xa0;g/g. Compared with traditional glucose culture medium, co-substrate fermentation improved the conversion rate of carbon sources and reduced PMA production cost by 14.9–36.6%. This work provides a new path for high-efficiency and economical industrial fermentation technology of PMA.</p>

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Co-substrate fermentation of lignocellulose with added glucose and xylose to increase production of poly (β-l-malic acid)

  • 期刊论文

  • 发表日期：

    2025年4月30日

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  • Yutian Zhang,
  • Dongdong Zeng,
  • Jianing Li,
  • Xiaojun Ma,
  • Dongna Li,
  • Yachao Li

摘要

Co-substrate fermentation has become an essential approach to achieving high-efficiency and low-cost production of poly (β-l-malic acid) (PMA). Herein, sustainable rubberwood (Hevea brasiliensis) hydrolysate (RWH) was co-fermented by A. pullulans to synthesize PMA using glucose and xylose as co-substrate carbon sources. Moreover, vitamin B was explored as nutrient supplementation in this study. Results showed that compared with the single RWH substrate, the PMA production of co-substrate fermentation increased by 38–52%. Furthermore, the addition of VB6 promoted the utilization of substrates and shortened the fermentation cycle of PMA. During the scale-up fermentation, the PMA yield reached 0.50–0.54 g/g. Compared with traditional glucose culture medium, co-substrate fermentation improved the conversion rate of carbon sources and reduced PMA production cost by 14.9–36.6%. This work provides a new path for high-efficiency and economical industrial fermentation technology of PMA.