Background <p>Attachment-based interventions enjoy a growing evidence-base for their effectiveness. These interventions may be decomposed into practice elements and studied for how they may cluster differentially for different children. Exploring this could reshape how attachment-based interventions are applied, potentially enhancing their utility.</p> Objectives <p>To apply the Distillation and Matching Model to the empirical literature on attachment-based interventions to identify practice elements common across these interventions and to describe their occurrence for target populations.</p> Methods <p>In this systematic review, across 60 studies, 23 practice elements were extracted from 45 intervention protocols that were tested in trials to be effective on attachment, sensitivity, and/or parent–child interaction outcomes.</p> Results <p>Findings show that practice elements were most differentiated for child age (≤ 6&#xa0;months; 7&#xa0;months to 11&#xa0;years; 12–18&#xa0;years) although further differentiations were found for location, ethnicity, and risk status. While there is similarity across practice element profiles regarding the use of relationship-building, video-feedback, psychoeducation, and home-based approaches, some distinctions were observed. Interventions for younger infants frequently involved direct demonstration and modelling, while those for older infants and young children consisted of feedback-based approaches. Interventions for vulnerable, at-risk parents consisted of intensive guidance, while those for groups indigenous to North America benefitted from a comprehensive, multifaceted package of practice elements. Interventions for adolescent-aged children were frequently implemented in parent-group format, involving role-plays and discussions between parents, with limited direct involvement of the child.</p> Conclusions <p>These distinctions may inform differential clinical applications of attachment-based interventions informed by the needs of specific populations.</p>