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<p>Thyroid cancer treatment and bacterial infection management have long been challenging due to the limited effectiveness and side effects of conventional therapies. Here, we introduce molybdenum nitride (Mo₂N) nanomaterials as an innovative platform for dual-functional photothermal therapy, combining anti-tumor and antibacterial treatments. Mo₂N nanoparticles with an average diameter of ~ 2.45&#xa0;nm were synthesized and systematically characterized. Upon near-infrared (NIR) laser exposure, Mo₂N demonstrated efficient photothermal conversion (efficiency ≈ 31.8%), leading to significant temperature elevation. <i>In vitro</i> studies confirmed a selective cytotoxic effect, with Mo₂N-mediated PTT inducing significant death in thyroid cancer cells while having a minimal impact on normal endothelial cells. <i>In vivo</i>, this platform led to significant tumor growth inhibition and accelerated healing of MRSA-infected wounds. Additionally, Mo₂N exhibited substantial antibacterial activity against <i>Escherichia coli</i> and <i>methicillin-resistant Staphylococcus aureus</i> (<i>MRSA</i>) under NIR irradiation, showcasing its effectiveness in combating bacterial infections. The combined anti-tumor and antibacterial actions of Mo₂N suggest a promising strategy for dual-functional photothermal therapy, where the photothermal effect not only inhibits tumor growth but also effectively eliminates bacterial infections during treatment. These findings indicate that Mo₂N-based photothermal therapy can serve as a versatile, multi-functional therapeutic tool, presenting a significant advancement in both oncology and infectious disease treatment.</p> Graphical Abstract <p><b>Graphical Headlights. Schematic illustration of the synthesis and applications of Mo₂N nanomaterials for antibacterial and anti-cancer therapy.</b> (i) Material Synthesis: Mo₂N nanomaterials were synthesized by reacting aniline with HCl and GO, followed by stirring, centrifugation, addition of ammonium molybdate tetrahydrate, freeze-drying, and finally thermal treatment in a tubular furnace. (ii) Antibacterial and Wound Healing: Under 808&#xa0;nm NIR irradiation, the Mo₂N nanomaterials accelerate wound healing by eliminating MRSA, reducing inflammation, and promoting tissue regeneration. (iii) Antineoplastic Activity: When exposed to NIR light, the nanomaterials induce selective cell death in thyroid cancer cells while showing minimal toxicity to normal cells, as further validated in an <i>in vivo</i> mouse model.</p> <p></p>

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Dual-functional Mo₂N nanomaterials for photothermal therapy: enhancing MRSA-infected wound healing and selective thyroid cancer ablation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月2日

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  • Wei Zhang,
  • Shixi Wu,
  • Chengze Chen

摘要

Thyroid cancer treatment and bacterial infection management have long been challenging due to the limited effectiveness and side effects of conventional therapies. Here, we introduce molybdenum nitride (Mo₂N) nanomaterials as an innovative platform for dual-functional photothermal therapy, combining anti-tumor and antibacterial treatments. Mo₂N nanoparticles with an average diameter of ~ 2.45 nm were synthesized and systematically characterized. Upon near-infrared (NIR) laser exposure, Mo₂N demonstrated efficient photothermal conversion (efficiency ≈ 31.8%), leading to significant temperature elevation. In vitro studies confirmed a selective cytotoxic effect, with Mo₂N-mediated PTT inducing significant death in thyroid cancer cells while having a minimal impact on normal endothelial cells. In vivo, this platform led to significant tumor growth inhibition and accelerated healing of MRSA-infected wounds. Additionally, Mo₂N exhibited substantial antibacterial activity against Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA) under NIR irradiation, showcasing its effectiveness in combating bacterial infections. The combined anti-tumor and antibacterial actions of Mo₂N suggest a promising strategy for dual-functional photothermal therapy, where the photothermal effect not only inhibits tumor growth but also effectively eliminates bacterial infections during treatment. These findings indicate that Mo₂N-based photothermal therapy can serve as a versatile, multi-functional therapeutic tool, presenting a significant advancement in both oncology and infectious disease treatment.

Graphical Abstract

Graphical Headlights. Schematic illustration of the synthesis and applications of Mo₂N nanomaterials for antibacterial and anti-cancer therapy. (i) Material Synthesis: Mo₂N nanomaterials were synthesized by reacting aniline with HCl and GO, followed by stirring, centrifugation, addition of ammonium molybdate tetrahydrate, freeze-drying, and finally thermal treatment in a tubular furnace. (ii) Antibacterial and Wound Healing: Under 808 nm NIR irradiation, the Mo₂N nanomaterials accelerate wound healing by eliminating MRSA, reducing inflammation, and promoting tissue regeneration. (iii) Antineoplastic Activity: When exposed to NIR light, the nanomaterials induce selective cell death in thyroid cancer cells while showing minimal toxicity to normal cells, as further validated in an in vivo mouse model.