<p>Bone marrow-derived cells in the tumor microenvironment, including macrophages, neutrophils, dendritic cells, myeloid-derived suppressor cells, eosinophils and basophils, participate in the generation, development, invasion and metastasis of tumors by producing different cytokines and interacting with other cell types, and play a pro-tumor or anti-tumor role in regulating tumor immunity. Due to the complexity of cell types in the tumor microenvironment and the unknown process of tumor development and metastasis, cancer treatment to achieve better survival status remains challenging. In this article, we summarize the effects of myeloid cells in tumor microenvironment on tumor immunity, cancer migration, and crosstalk with metabolism (including glucose metabolism, lipid metabolism, and amino acid metabolism), which will help to further study the tumor microenvironment and seek targeted therapeutic strategies for patients.</p> Graphical abstract <p>Myeloid cells in the tumor microenvironment exhibit diverse biological functions, influencing tumor initiation and progression. Myeloid cells are involved in tumor immunity and metastasis processes, interacting with other immune cell types to affect the tumor immune response. The crosstalk between glucose metabolism, lipid metabolism, amino acid metabolism, and myeloid cells impacts tumor immunity and metastasis.</p> <p></p>