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<p>Bone disorders affect more than half of the adult population worldwide who may have a poor quality of life and physical independence worldwide. Multi-omic techniques are increasingly adopted and applied to determine the molecular mechanisms of bone tissue repair, providing perspective towards personalized medical intervention. Data from genomics, epigenomics, transcriptomics, proteomics, glycomics, and lipidomics were combined to elucidate dynamic processes in bone repair. In this narrative review, the key role of genetic and epigenetic factors in regulating injured cellular responses is highlighted, and changes in RNA and protein expression during the healing phase, as well as glucolipid metabolism adaptation, are described in detail how the repair process is affected. In a word, the integration of multi-omic techniques in this review not only benefits the comprehensive identification of new biomarkers, but also facilitates the development of personalized treatment strategies of bone disorders to revolutionize regenerative medicine.</p> Graphical abstract <p>1.Multi-omic techniques have been applied for exploring human bone respair.</p> <p>2.Bone respair process included inflammatory, reparative, remodeling phases with multiple gene expressions, such as BMPs.</p> <p>3.Various miRNA and protein expressions involved in osteogenesis, serving as promising therapeutic targets for bone respair.</p> <p></p>

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Repair mechanisms of bone system tissues based on comprehensive perspective of multi-omics

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月18日

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  • Honghao Yu,
  • Shize Yang,
  • Tianlong Jiang,
  • Tian Li,
  • Hongmei Duan,
  • Minglei Li

摘要

Bone disorders affect more than half of the adult population worldwide who may have a poor quality of life and physical independence worldwide. Multi-omic techniques are increasingly adopted and applied to determine the molecular mechanisms of bone tissue repair, providing perspective towards personalized medical intervention. Data from genomics, epigenomics, transcriptomics, proteomics, glycomics, and lipidomics were combined to elucidate dynamic processes in bone repair. In this narrative review, the key role of genetic and epigenetic factors in regulating injured cellular responses is highlighted, and changes in RNA and protein expression during the healing phase, as well as glucolipid metabolism adaptation, are described in detail how the repair process is affected. In a word, the integration of multi-omic techniques in this review not only benefits the comprehensive identification of new biomarkers, but also facilitates the development of personalized treatment strategies of bone disorders to revolutionize regenerative medicine.

Graphical abstract

1.Multi-omic techniques have been applied for exploring human bone respair.

2.Bone respair process included inflammatory, reparative, remodeling phases with multiple gene expressions, such as BMPs.

3.Various miRNA and protein expressions involved in osteogenesis, serving as promising therapeutic targets for bone respair.