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Abstract <p>The Biginelli reaction products have significant medicinal and biological applications, prompting the need for green chemistry-compatible catalytic systems for their synthesis. This project introduces aluminum ferrite nanoparticles (AlFeO<sub>3</sub> NPs) as an efficient and eco-friendly catalyst for creating Biginelli derivatives through three-component reactions involving aryl and heteroaryl aldehydes, ethyl or methyl acetoacetate, and thiourea in glycerol. The AlFeO<sub>3</sub> NPs catalyst was synthesized from readily available materials and characterized using various techniques, including FT-IR, XRD, VSM, TGA, BET, SEM, TEM, and EDX, confirming its structure and magnetic properties. Notably, this method allows for the rapid synthesis of 19 derivatives of 3, 4-Dihydropyrimidin-2(1<i>H</i>)-thione with high yields, utilizing environmentally friendly solvents and adhering to green chemistry principles.</p> Graphical Abstract <p></p>

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Green Utilizing AlFeO3 Nanoparticles-Catalyzed for Sustainable Biginelli Synthesis of 3, 4-Dihydropyrimidin-2(1H)-thiones in Glycerol

  • 期刊论文

  • 发表日期：

    2025年3月11日

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  • Fadhil Faez Sead,
  • Vicky Jain,
  • Anjan Kumar,
  • Subbulakshmi Ganesan,
  • Aman Shankhyan,
  • Mukesh Kumari,
  • Pushpa Negi Bhakuni,
  • Mosstafa Kazemi,
  • Ramin Javahershenas

摘要

Abstract

The Biginelli reaction products have significant medicinal and biological applications, prompting the need for green chemistry-compatible catalytic systems for their synthesis. This project introduces aluminum ferrite nanoparticles (AlFeO3 NPs) as an efficient and eco-friendly catalyst for creating Biginelli derivatives through three-component reactions involving aryl and heteroaryl aldehydes, ethyl or methyl acetoacetate, and thiourea in glycerol. The AlFeO3 NPs catalyst was synthesized from readily available materials and characterized using various techniques, including FT-IR, XRD, VSM, TGA, BET, SEM, TEM, and EDX, confirming its structure and magnetic properties. Notably, this method allows for the rapid synthesis of 19 derivatives of 3, 4-Dihydropyrimidin-2(1H)-thione with high yields, utilizing environmentally friendly solvents and adhering to green chemistry principles.

Graphical Abstract