<p>A simple, cost-effective, and green method is reported for the multicomponent synthesis of heterocyclic compounds, specifically 1,8-dioxodecahydroacridine and polyhydroquinoline derivatives, which are important scaffolds in pharmaceutical and medicinal chemistry, using 20 mg of phosphatidylcholine (PC) as a natural and biodegradable catalyst. The reactions were performed under mild conditions, either in water or under solvent-free conditions. The 1,8-dioxodecahydroacridine derivatives were obtained in excellent yields of up to 97% within 50 min, while polyhydroquinoline derivatives were synthesized in yields of up to 95% within only 8 min. The structures of the synthesized compounds were confirmed by melting point and FT-IR analysis. Furthermore, the catalyst could be easily recovered and reused for four consecutive cycles without significant loss of catalytic activity. Overall, this method provides an efficient, practical, and environmentally friendly strategy for the synthesis of valuable heterocyclic compounds.</p> Graphycal abstract <p></p>