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<p>In this study, Nickel-Aluminum Takovite (NiAl-Takovite) was developed as an effective heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2(1&#xa0;H)-ones (DHPMs) through the Biginelli cyclocondensation reaction. The catalyst was prepared using a coprecipitation method and characterized by TG-dTG, FT-IR, XRD, N<sub>2</sub> adsorption-desorption, and SEM-EDX analyses to examine its structure, microstructure, and composition. NiAl–Takovite exhibited excellent catalytic performance, facilitating the rapid synthesis of DHPMs derivatives with yields of up to 90%. The products were characterized by NMR spectroscopy and evaluated for their antimicrobial activity against bacterial and fungal species. The distinctive structural features of the catalyst, its surface basicity, and textural properties underlie its high efficiency, offering an environmentally friendly and sustainable strategy for the production of bioactive DHPMs as potential antimicrobial agents.</p> Graphical Abstract <p></p>

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NiAl-Takovite as a Sustainable Catalyst for the Synthesis of Antimicrobial DHPMs Compounds via Biginelli Reaction

  • 期刊论文

  • 发表日期：

    2026年1月31日

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  • Ouhaddou Madani,
  • Dib Mustapha,
  • Idrissi Yahyaoui Meryem,
  • Kacem Marieme,
  • Ouchetto Hajiba,
  • Rokni Yahya,
  • Asehraou Abdeslam,
  • Khouili Mostafa,
  • Hafid Abderrafia

摘要

In this study, Nickel-Aluminum Takovite (NiAl-Takovite) was developed as an effective heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2(1 H)-ones (DHPMs) through the Biginelli cyclocondensation reaction. The catalyst was prepared using a coprecipitation method and characterized by TG-dTG, FT-IR, XRD, N2 adsorption-desorption, and SEM-EDX analyses to examine its structure, microstructure, and composition. NiAl–Takovite exhibited excellent catalytic performance, facilitating the rapid synthesis of DHPMs derivatives with yields of up to 90%. The products were characterized by NMR spectroscopy and evaluated for their antimicrobial activity against bacterial and fungal species. The distinctive structural features of the catalyst, its surface basicity, and textural properties underlie its high efficiency, offering an environmentally friendly and sustainable strategy for the production of bioactive DHPMs as potential antimicrobial agents.

Graphical Abstract