Unravelling the Synthesis of 2-Aminobenzo[d]thiazole Derivatives via a Novel Zinc(II)-Catalyzed Strategy

The first zinc(II)-catalyzed approach towards an array of 2-aminobenzothiazole derivatives was successfully developed. In this process, the substrate 2-bromophenyl isothiocyanate was reacted with a range of amines, including aromatic and aliphatic (primary and secondary) and cyclic secondary amines, yielding the products in reasonably good amounts. The reactivity analyses of different amines revealed that cyclic secondary amines performed exceptionally well, providing excellent outcomes. Additionally, aliphatic amines also exhibited the capability to undergo the transformation successfully.