Polymer Supported Ferric Chloride as Heterogeneous Catalyst for Three Component Biginelli Reaction
摘要
Polymer supported ferric chloride catalyst is prepared and characterized by IR, SEM, TEM, EDS, TGA, ICP-MS and XRD. The heterogenized Lewis acid catalyst was found to efficiently promote three component Biginelli reaction, where the 3,4-dihydropyrimidine-2(1H)-ones/thiones were efficiently synthesized from urea/thiourea. The catalyst was found to be quite robust for this reaction with very less leaching of metal was observed, and hence can be efficiently recycled. The catalyst was found to be effective for multiple uses, establishing its reusability in this important reaction.
Graphical Abstract