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<p>Cardiovascular disease (CVD) represents a significant global health challenge, with its high incidence and mortality rates placing a substantial burden on both patients and society. Although conventional therapies have achieved certain results, they continue to face considerable limitations. In recent years, therapeutic ultrasound has emerged as a promising medical technology, offering notable potential in the treatment of CVD owing to its non-invasiveness, safety, and targeting precision. Low-intensity pulsed ultrasound (LIPUS), a form of therapeutic ultrasound, uses pulsed, low-intensity, moderate-frequency acoustic waves to produce biological effects. This modality minimizes thermal impact while enhancing mechanical interactions. Another well-regarded technique is ultrasound-targeted microbubble destruction (UTMD), an innovative gene delivery system characterized by safety, reliable targeting, and high personalization. In clinical practice for CVD, both LIPUS and UTMD exhibit distinct advantages. This review examines the current landscape of CVD and discusses the potential and future applications of LIPUS and UTMD in their management.</p>

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Therapeutic Ultrasound in Cardiovascular Medicine: Applications of Low-intensity Pulsed Ultrasound and Ultrasound-targeted Microbubble Destruction

  • 期刊论文

  • 发表日期：

    2026年3月7日

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  • Yucong Shi,
  • Yongqing Ye,
  • Shanshan Chang,
  • Dongxu Lu,
  • Yinzhu Chu

摘要

Cardiovascular disease (CVD) represents a significant global health challenge, with its high incidence and mortality rates placing a substantial burden on both patients and society. Although conventional therapies have achieved certain results, they continue to face considerable limitations. In recent years, therapeutic ultrasound has emerged as a promising medical technology, offering notable potential in the treatment of CVD owing to its non-invasiveness, safety, and targeting precision. Low-intensity pulsed ultrasound (LIPUS), a form of therapeutic ultrasound, uses pulsed, low-intensity, moderate-frequency acoustic waves to produce biological effects. This modality minimizes thermal impact while enhancing mechanical interactions. Another well-regarded technique is ultrasound-targeted microbubble destruction (UTMD), an innovative gene delivery system characterized by safety, reliable targeting, and high personalization. In clinical practice for CVD, both LIPUS and UTMD exhibit distinct advantages. This review examines the current landscape of CVD and discusses the potential and future applications of LIPUS and UTMD in their management.