Effect of Statin Treatment on Lipoprotein-Associated Phospholipase A2 Mass and Activity: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials

期刊论文
发表日期：

2024年10月28日

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Amirhossein Sahebkar,
Željko Reiner,
Wael Almahmeed,
Tannaz Jamialahmadi,
Luis E. Simental-Mendía

摘要

Purpose

The goal of this meta-analysis was to establish whether statin treatment reduces Lp-PLA2 mass concentration and/or activity.

Methods

PubMed, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases were searched using MESH terms and keywords. Randomized controlled trials (RCT) with either parallel or cross-over design examining the effect of statins on Lp-PLA2 mass and/or activity were included in meta-analysis.

Results

Out of 256 articles, 10 RCT were selected for meta-analysis. Statin therapy significantly reduced both Lp-PLA2 mass (WMD −44.46 ng/mL; 95%CI −59.01, −29.90; p < 0.001; I² = 93%) and activity (WMD −39.37 nmol/min/mL; 95%CI −69.99, −8.75; p = 0.01; I² = 100%). The sensitivity analysis was robust for Lp-PLA2 mass and was also positive for two studies concerning Lp-PLA2 activity.

Conclusion

Statin therapy significantly reduced both Lp-PLA2 mass and activity.