Scholarlink

<p> Non-smoking lung cancer, characterized by early onset and predominant EGFR mutations, has been listed as a separate disease entity and is the seventh leading cause of cancer-related death worldwide. Its incidence remains a significant health problem globally, especially in East Asia and most predominantly among women. The reason for this higher incidence in women (lung cancer in non-smoking women, LCINSW) is still not yet clear, but gender differences provide strong evidence for the genetic as well as environmental contribution at play. In the current review, we summarized the recent research on LCINSW, which systematically unveiled their clinical characteristics and epidemiological changes, risk factors, molecular pathology, and response to treatment and survival, providing an overview of the critical role that gender susceptibility plays in LCINSW, establishing a theoretical foundation for enhancing patient prognosis with an emphasis on further research to continue elucidating underlying mechanisms behind LCINSW.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Lung cancer in non-smoking women (LCINSW): from risk factors to precision therapy

  • 期刊论文

  • 发表日期：

    2025年9月30日

查看全文
  • Jinming Zhao,
  • Mingjun Li,
  • Limin Niu,
  • Yajing Zhao,
  • Xingguo Song

摘要

Non-smoking lung cancer, characterized by early onset and predominant EGFR mutations, has been listed as a separate disease entity and is the seventh leading cause of cancer-related death worldwide. Its incidence remains a significant health problem globally, especially in East Asia and most predominantly among women. The reason for this higher incidence in women (lung cancer in non-smoking women, LCINSW) is still not yet clear, but gender differences provide strong evidence for the genetic as well as environmental contribution at play. In the current review, we summarized the recent research on LCINSW, which systematically unveiled their clinical characteristics and epidemiological changes, risk factors, molecular pathology, and response to treatment and survival, providing an overview of the critical role that gender susceptibility plays in LCINSW, establishing a theoretical foundation for enhancing patient prognosis with an emphasis on further research to continue elucidating underlying mechanisms behind LCINSW.