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<p>While the normal ranges of myocardial T1 and T2 have been vastly reported, the studies on blood T2 are limited and data is sparse. The purpose of this study was to report the age and sex distribution of right (RV) and left ventricular (LV) blood T2 in the human heart and to evaluate their relationships to lung volume. 156 asymptomatic adults without hypertension or diabetes and free from cardiopulmonary disease (74 men, mean age 50 ± 14 years, range 24–81 years) were included. 3T MRI including cardiac scout and T2-prepared gradient-echo sequence for T2 mapping were acquired with breath hold in the resting lung position (i.e. functional residual capacity, FRC). T2 maps were used to measure blood T2 times. MRI-estimated FRC (MRI-eFRC) was measured using a single scout image in the coronal orientation and was assessed by delineation of the chest wall manually excluding the heart. Men had higher MRI-eFRC (<i>p</i> = 0.002) and LV blood T2 (99 ± 24 ms vs. 91 ± 21 ms, <i>p</i> = 0.03) than women but RV blood T2 were similar (81 ± 12 ms vs. 78 ± 11 ms, <i>p</i> = 0.2). Both MRI-eFRC (<i>r</i> = 0.17, <i>p</i> = 0.04) and LV blood T2 (<i>r</i> = 0.33, <i>p</i> &lt; 0.0001) were positively correlated with age, while RV blood T2 did not show age dependence. MRI-eFRC was also positively correlated with LV blood T2 (<i>r</i> = 0.18, <i>p</i> = 0.02) but not with RV blood T2. Ventricular T2 values exhibited good intra- and inter-observer reproducibility (coefficient of variation &lt; 3%). Our study provides the normal ranges of ventricular blood T2 relaxation times in sex and age groups using the T2-prepared gradient echo sequence at 3T and demonstrated that LV blood T2 is positively associated with age, which may serve as a basis for future studies for clinical CMR examination involving patients with diseases altering these parameters.</p>

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Ventricular blood T2 in asymptomatic adults at 3T: effect of age and lung volume by magnetic resonance imaging

  • 期刊论文

  • 发表日期：

    2025年8月12日

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  • Chia-Ying Liu,
  • Chikara Noda,
  • Bharath Ambale-Venkatesh,
  • Yoko Kato,
  • Yoshimori Kassai,
  • David A. Bluemke,
  • Aparna Balasubramanian,
  • João A.C. Lima

摘要

While the normal ranges of myocardial T1 and T2 have been vastly reported, the studies on blood T2 are limited and data is sparse. The purpose of this study was to report the age and sex distribution of right (RV) and left ventricular (LV) blood T2 in the human heart and to evaluate their relationships to lung volume. 156 asymptomatic adults without hypertension or diabetes and free from cardiopulmonary disease (74 men, mean age 50 ± 14 years, range 24–81 years) were included. 3T MRI including cardiac scout and T2-prepared gradient-echo sequence for T2 mapping were acquired with breath hold in the resting lung position (i.e. functional residual capacity, FRC). T2 maps were used to measure blood T2 times. MRI-estimated FRC (MRI-eFRC) was measured using a single scout image in the coronal orientation and was assessed by delineation of the chest wall manually excluding the heart. Men had higher MRI-eFRC (p = 0.002) and LV blood T2 (99 ± 24 ms vs. 91 ± 21 ms, p = 0.03) than women but RV blood T2 were similar (81 ± 12 ms vs. 78 ± 11 ms, p = 0.2). Both MRI-eFRC (r = 0.17, p = 0.04) and LV blood T2 (r = 0.33, p < 0.0001) were positively correlated with age, while RV blood T2 did not show age dependence. MRI-eFRC was also positively correlated with LV blood T2 (r = 0.18, p = 0.02) but not with RV blood T2. Ventricular T2 values exhibited good intra- and inter-observer reproducibility (coefficient of variation < 3%). Our study provides the normal ranges of ventricular blood T2 relaxation times in sex and age groups using the T2-prepared gradient echo sequence at 3T and demonstrated that LV blood T2 is positively associated with age, which may serve as a basis for future studies for clinical CMR examination involving patients with diseases altering these parameters.