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<p>This cohort study aims to evaluate the capability of non-invasive left ventricular pressure-strain loop (LV-PSL) analysis using myocardial work parameters to predict coronary artery occlusion in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). A total of 113 patients suspected of having NSTE-ACS underwent PSL analysis prior to coronary angiography to obtain myocardial work parameters such as global work index (GWI), global constructive work (GCW), global wasted work (GWW), and work efficiency (GWE). Based on the results of coronary angiography, patients were categorized into two groups: non-occluded (65 cases) and occluded (26 cases). The study compared differences in left ventricular global longitudinal strain (GLS) and myocardial work parameters between the groups and assessed the predictive value of these parameters for diagnosing coronary artery occlusion. The occluded group exhibited significantly higher GWI, GCW, and GWE values and lower GLS and GWW values (<i>P</i> &lt; 0.05). The area under the curve (AUC) for detecting coronary occlusion was superior for GWI compared to GLS, GCW, GWW, and GWE. Additionally, combining GLS with myocardial work parameters improved diagnostic efficacy (<i>P</i> = 0.016). GWI-focused LV-PSL analysis more effectively detects coronary occlusion in NSTE-ACS, guiding early intervention and improving diagnostic accuracy.</p>

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Non-invasive left ventricular pressure-strain loop in predicting coronary artery occlusion in patients with non-ST segment elevation acute coronary syndrome: a cohort study

  • 期刊论文

  • 发表日期：

    2025年6月27日

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  • Yao Huang,
  • Lingping Huang,
  • Guangrui Feng,
  • Huirong Sun,
  • Jian Wu,
  • Wei Hu

摘要

This cohort study aims to evaluate the capability of non-invasive left ventricular pressure-strain loop (LV-PSL) analysis using myocardial work parameters to predict coronary artery occlusion in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). A total of 113 patients suspected of having NSTE-ACS underwent PSL analysis prior to coronary angiography to obtain myocardial work parameters such as global work index (GWI), global constructive work (GCW), global wasted work (GWW), and work efficiency (GWE). Based on the results of coronary angiography, patients were categorized into two groups: non-occluded (65 cases) and occluded (26 cases). The study compared differences in left ventricular global longitudinal strain (GLS) and myocardial work parameters between the groups and assessed the predictive value of these parameters for diagnosing coronary artery occlusion. The occluded group exhibited significantly higher GWI, GCW, and GWE values and lower GLS and GWW values (P < 0.05). The area under the curve (AUC) for detecting coronary occlusion was superior for GWI compared to GLS, GCW, GWW, and GWE. Additionally, combining GLS with myocardial work parameters improved diagnostic efficacy (P = 0.016). GWI-focused LV-PSL analysis more effectively detects coronary occlusion in NSTE-ACS, guiding early intervention and improving diagnostic accuracy.