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Purpose <p>To estimate the incidence rates of second primary cancers (SCPs) [diagnosed &gt; 2&#xa0;months after a first primary cancer (FPC)], and cumulative incidence and mortality of metachronous SPCs in patients with a cervical, uterine, or ovarian FPC, and to compare the incidence of SPCs with that expected in the general female population.</p> Methods <p>A cohort of patients with cervical, uterine, or ovarian FPC from the North Region Cancer Registry of Portugal, diagnosed in 2000–2010 (<i>n</i> = 5846) was followed until 31/12/2015 for synchronous and metachronous SPCs. Cumulative incidence of metachronous SPCs considering death as a competing event, and incidence rates and standardized incidence ratios (SIR) of SPCs were estimated.</p> Results <p>Diagnosis of an SPC occurred in 541 (9.3%) patients at a median age of 60&#xa0;years. SPCs were more frequent among patients with uterine cancers. Colon, breast, and corpus uteri were the most common sites for an SPC among patients with a gynecological FPC. A higher incidence of all and individual SPCs compared to the general female population was found (SIR = 1.96, 95% CI 1.79–2.12) with the most relevant sites being cancers of the colon (SIR = 2.32, 95% CI 1.82–2.89), lung (SIR = 2.70, 95% CI 1.88, 3.66), cervix (SIR = 4.87, 95% CI 3.43, 6.56), corpus uteri (SIR = 5.37, 95% CI 4.16, 6.73) and ovary (SIR = 6.06, 95% CI 4.12–8.37). The 10-year cumulative incidence of a metachronous SPC and death for patients with a gynecological FPC was 7.4% and 39.2%, respectively.</p> Conclusion <p>In Portugal, patients with a gynecological FPC have a higher incidence of SPCs compared to the general female population, particularly elderly females. Increased surveillance and counselling among these patients are needed.</p>

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Second primary cancers among females with a first primary cervical, uterine and ovarian cancer: a population-based study in North Portugal

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Elisabete Gonçalves,
  • Filipa Fontes,
  • Jéssica Rocha Rodrigues,
  • Rita Calisto,
  • Maria José Bento,
  • Nuno Lunet,
  • Samantha Morais

摘要

Purpose

To estimate the incidence rates of second primary cancers (SCPs) [diagnosed > 2 months after a first primary cancer (FPC)], and cumulative incidence and mortality of metachronous SPCs in patients with a cervical, uterine, or ovarian FPC, and to compare the incidence of SPCs with that expected in the general female population.

Methods

A cohort of patients with cervical, uterine, or ovarian FPC from the North Region Cancer Registry of Portugal, diagnosed in 2000–2010 (n = 5846) was followed until 31/12/2015 for synchronous and metachronous SPCs. Cumulative incidence of metachronous SPCs considering death as a competing event, and incidence rates and standardized incidence ratios (SIR) of SPCs were estimated.

Results

Diagnosis of an SPC occurred in 541 (9.3%) patients at a median age of 60 years. SPCs were more frequent among patients with uterine cancers. Colon, breast, and corpus uteri were the most common sites for an SPC among patients with a gynecological FPC. A higher incidence of all and individual SPCs compared to the general female population was found (SIR = 1.96, 95% CI 1.79–2.12) with the most relevant sites being cancers of the colon (SIR = 2.32, 95% CI 1.82–2.89), lung (SIR = 2.70, 95% CI 1.88, 3.66), cervix (SIR = 4.87, 95% CI 3.43, 6.56), corpus uteri (SIR = 5.37, 95% CI 4.16, 6.73) and ovary (SIR = 6.06, 95% CI 4.12–8.37). The 10-year cumulative incidence of a metachronous SPC and death for patients with a gynecological FPC was 7.4% and 39.2%, respectively.

Conclusion

In Portugal, patients with a gynecological FPC have a higher incidence of SPCs compared to the general female population, particularly elderly females. Increased surveillance and counselling among these patients are needed.